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Migalastat hydrochloride
CAS No. 75172-81-5
Migalastat hydrochloride( —— )
Catalog No. M33025 CAS No. 75172-81-5
Migalastat hydrochloride (GR181413A) is an orally available, potent and competitive inhibitor of alpha-galactosidase A.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 47 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMigalastat hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionMigalastat hydrochloride (GR181413A) is an orally available, potent and competitive inhibitor of alpha-galactosidase A.
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DescriptionMigalastat hydrochloride (GR181413A) is a potent and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC50 of 0.04 μM for human α-Gal A.
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In VitroCell Viability AssayCell Line:EHK cells mutated α-Gal A Concentration:10 μM Incubation Time:9 days Result:Reduced Gb3 accumulation and lysosome volume.
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In VivoAnimal Model:Male nontransgenic (Non-Tg) C57BL/6 mice; transgenic mice expressing human mutant R301Q α-Gal A (TgM), α-Gal A knockout mice (KO), mice express human R301Q α-Gal A in a null background (TgM/KO) Dosage:3 mg/kg Administration: Oral gavage; every day for 4 weeks Result:Reduced Globotriaosylceramide (Gb3) storage remarkably in kidney of mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number75172-81-5
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Formula Weight199.63
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Molecular FormulaC6H14ClNO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : ≥ 200 mg/mL (1001.85 mM)
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SMILESCl.OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Asano N, et al. In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives. Eur J Biochem. 2000 Jul;267(13):4179-86.?
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